BREATHE EASY SOLSTICE® AIR

An ultra-low global warming potential (GWP) Propellant For Metered Dose Inhalers

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A Breakthrough Technology for Pressurized Metered Dose Inhalers (pMDI)

The future of metered dose inhalers (MDI) demands both technical excellence and environmental responsibility. Explore how Solstice® Air is transforming MDI technology through non-flammable, sustainable propellant solutions.

Earth-Friendly

Near-Zero GWP vs. 134a, 227ea and 152a 

Good Safety Profile

Pre-clinical toxicity studies concluded a good safety profile for use in Metered Dose Inhalers.

Important Global Solution

Next Generation HFO technology provides excellent solutions to the global phase-down of high-GWP HFCs under the Kigali amendment to the Montreal Protocol.

Non-flammable

A UN class 2.2 non-flammable liquefied gas. It is classified as non-flammable according to EC A11 and ASTM E681.

News, Events & Updates

REGULATORY APPROVAL
First Inhaled Respiratory Medicine Using Solstice® Air Has Been Approved in the UK

First Inhaled Respiratory Medicine Using Solstice® Air has been approved in the UK and received a positive EU CHMP opinion .

REPORT
Explore the Latest Research on Solstice® Air
Unlock valuable insights and stay updated on Solstice® Air (HFO-1234ze(E)). Complete the form below to access our comprehensive research list, and we'll deliver the report straight to your inbox.
case study
Breathe Easy Bespak Leads the Way With Planet-friendly pMDI Propellent
Solstice® Air is safe, nonflammable and better for the environment. Learn how Bespak became the first CDMO to utilize Solstice Air in the manufacturing of pressured pMDIs.

Why Solstice Air is a Gamechanger for the Pharmaceutical Industry?

As many as 384 million people suffer from chronic obstructive pulmonary disease (COPD), a progressive respiratory disease, and 339 million children and adults suffer from asthma.1,2 Many of these patients are currently treated using pressurized metered dose inhalers (pMDIs) that use hydrofluorocarbons (HFCs) that can contribute to the global carbon footprint of respiratory care. Honeywell’s Solstice Air (HFO-1234ze(E) cGMP) is an alternative technology as a medical propellant, reducing the greenhouse gas emissions of pMDIs by up to 99.9% when compared to current inhaler propellants. Solstice Air is the only non-flammable, near-zero GWP propellant available and in clinical development today for pMDIs.

Solstice Air Resources

Accelerating the Transition to Lower Greenhouse Gas Respiratory Care

Honeywell and Recipharm have joined forces to speed up the development of inhalers made with near-zero GWP propellant, Honeywell Solstice Air. 

Honeywell Solstice® Air is an alternative to HFCs in MDI

Solstice Air is VOC-exempt per the U.S. Environmental Protection Agency (EPA) and the California Air Resource Board (CARB). 

Eliminating Greenhouse Gas Emissions One Breath at a Time

Solstice Air (HFO-1234ze(E), cGMP) can reduce greenhouse gas emissions of propellant by up to 99.9% vs. current inhaler propellant. 

Solstice Air Redefines Respiratory Care

Engineered for safe, effective pMDIs with low global warming potential technology.

Partnerships

Honeywell Teams With AstraZeneca To Develop Next-Generation Respiratory Inhalers That Use Near-Zero Global Warming Potential Propellant

Honeywell And Recipharm To Speed Development Of Inhalers With A Near-Zero Global Warming Potential Propellant

Honeywell Technology To Power DevPro Biopharma’s Next-generation Low-Emission Respiratory Inhaler

Lupin And Honeywell Move Forward Jointly With Plans For HFO Technology In Inhalers

Ready to Test Solstice Air?

Samples of Solstice Air are available for testing.  To request a sample, please complete the form below.

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1 Bodkin, Henry (2019-04-08). "Asthma inhalers as bad for the environment as 180-mile car journey, health chiefs say"The TelegraphISSN 0307-1235

2 World Health Organization. The top 10 causes of death. [Online. Available at: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death]

*These are just some of a mosaic of properties that must be considered in identifying a suitable propellant.